Mpro/PLpro-IN-1

• Description:

  Mpro/PLpro-IN-1 (Compound 29) is a potent inhibitor of Mpro/PLpro. Mpro/PLpro-IN-1 is a dual acting SARS-CoV-2 proteases inhibitor featuring micromolar inhibitory potency versus Mpro (IC50 = 1.72 μM) and submicromolar potency versus PLpro (IC50 = 0.67 μM) [1].

• UNSPSC:

  12352005

• Target:

  SARS-CoV

• Type:

  Reference compound

• Related Pathways:

  Anti-infection

• Applications:

  COVID-19-anti-virus

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/mpro-plpro-in-1.html

• Solubility:

  10 mM in DMSO

• Smiles:

  C=CC[C@H](NC(CCl)=O)C(N[C@@H](CC1=CNC2=C1C=CC=C2)C(NCC3=CC=CC=C3)=O)=O

• Molecular Formula:

  C25H27ClN4O3

• Molecular Weight:

  466.96

• References & Citations:

  [1]Di Sarno V, et al. Identification of a dual acting SARS-CoV-2 proteases inhibitor through in silico design and step-by-step biological characterization. Eur J Med Chem. 2021;226:113863.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [2766185-78-6]