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SARS-CoV-2 PLpro-IN-2

CAT: 0804-HY-178160Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-178160Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SARS-CoV-2 PLpro-IN-2 (Compound 12) is a highly selective SARS-CoV-2 papain-like protease (PLpro) inhibitor of (IC50=0.06 μM) . SARS-CoV-2 PLpro-IN-2 inhibits viral replication and immune evasion. SARS-CoV-2 PLpro-IN-2 exhibits antiviral efficacy in HeLa-ACE2 cells (EC50=2.9 μM) . SARS-CoV-2 PLpro-IN-2 is promising for research of COVID-19[1].
CAS Number
1581755-42-1
UNSPSC
12352005
Target
SARS-CoV; Virus Protease
Related Pathways
Anti-infection
Field of Research
Infection
Smiles
C[C@@H](N1CCC(C(NCC2=CC=C(Cl)C=C2)=O)CC1)C3=CC=CC4=CC=CC=C43
Molecular Formula
C25H27ClN2O
Molecular Weight
406.95
References & Citations
[1]Gawriljuk VO, et al. Screening of Medicines for Malaria Venture Open Boxes Identifies Potent SARS-CoV‑2 Papain-like Protease (PLpro) Inhibitors. ACS Omega. 2025 Sep 11;10 (37) :42711-42724.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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