SDH-IN-24

• Description:

  SDH-IN-24 (Compound 51) is an inhibitor of succinate dehydrogenase (SDH) . The LC50 against the second-stage juveniles of Bursaphelenchus xylophilus (B. xylophilus) is 6.9 mg/L, and the IC50 for SDH is 15.0 μM. SDH-IN-24 exerts its nematicidal activity by inhibiting the activity of SDH to interfere with the energy metabolism of nematodes. Meanwhile, it inhibits the motility, feeding, and reproduction of nematodes, induces oxidative stress, reduces the protein content of nematodes, and impairs their antioxidant capacity. SDH-IN-24 can be used in the research related to anti-nematode fields[1].

• UNSPSC:

  12352005

• Target:

  Insecticide; Parasite

• Related Pathways:

  Anti-infection; Others

• Field of Research:

  Infection

• Smiles:

  O=C(NCC1=NOC(C2=CC=CS2)=N1)CBr

• Molecular Formula:

  C9H8BrN3O2S

• Molecular Weight:

  302.15

• References & Citations:

  [1]Chen X, et al. Design, Synthesis, and Nematicidal Activity of Novel Amide Derivatives Containing an 1,2,4/1,3,4-Oxadiazole Moiety against Bursaphelenchus xylophilus. J Agric Food Chem. 2025 Mar 26;73 (12) :7166-7178.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported