SK-124

• Description :

  SK-124 is an orally active, selective SIK2/SIK3 inhibitor. SK-124 inhibits SIK2 and SIK3. SK-124 increases P1NP and CTX. SK-124 increases bone formation and bone mass[1].

• UNSPSC :

  12352005

• Target :

  Salt-inducible Kinase (SIK)

• Related Pathways :

  Immunology/Inflammation

• Field of Research :

  Endocrinology

• Smiles :

  COC1=CC(C2=CN=C3C=C(C4=CN(C)N=C4)C=CN32)=CC(OC)=C1C5=NN=C(CC)O5

• Molecular Formula :

  C23H22N6O3

• Molecular Weight :

  430.46

• References & Citations :

  [1]Sato T, et al. Structure-based design of selective, orally available salt-inducible kinase inhibitors that stimulate bone formation in mice. Proc Natl Acad Sci U S A. 2022 Dec 13;119 (50) :e2214396119.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  SIK2; SIK3

• CAS Number :

  [2760404-50-8]