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IKZF2-degrader 2

CAT: 0013-GTR19275105-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19275105-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
IKZF2-degrader 2 is a selective, orally active molecular glue degrader for IKZF2, with DC50 values of 0.5 nM (HiBit) and 1.8 nM (FACS) . It facilitates ubiquitination and degradation of target proteins by recruiting the CRL4-CRBN E3 ubiquitin ligase. IKZF2-degrader 2 shows moderate degradation activity against SALL4 (DC50 of 9 nM) but does not significantly degrade IKZF1, IKZF3, CK1α, or GSPT1. This compound is suitable for research in cancer immunology.
CAS Number
2983841-00-3
Smiles
O=C1C=2C=CC (=C (F) C2CN1C3C (=O) NC (=O) CC3) C=4N=C5C (C=CN5C) =C (C4Cl) CN6CCCC6
Molecular Formula
C26H25ClFN5O3
Molecular Weight
509.97
Storage Conditions
-20°C
Notes
For research use only.

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