Ferroptosis inducer-7

• Description:

  Ferroptosis inducer-7 is an orally active and selective ferroptosis inducer via inositol 1,4,5-trisphosphate receptor (IP3R) /calcium release-activated calcium channel protein (ORAI) . Ferroptosis inducer-7 exhibits a notable effect in alleviating anemia symptoms, suppressing bone marrow CTLs activation, and improving hematopoietic function in immune-mediated bone marrow failure. Ferroptosis inducer-7 can be studied in research for aplastic anemia[1].

• UNSPSC:

  12352005

• Target:

  ERK; Ferroptosis; MEK; p38 MAPK

• Related Pathways:

  Apoptosis; MAPK/ERK Pathway; Stem Cell/Wnt

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Smiles:

  O=C(/C=C/C1=CC=CC=C1)OC2=C3[C@]45[C@@](C=C(C(C5)=O)OC)([H])[C@](N(CC4)C)([H])CC3=C(C=C2OC)CO

• Molecular Formula:

  C29H31NO6

• Molecular Weight:

  489.56

• References & Citations:

  [1]Zhang Z, et al., A Novel Compound 3a-M1, from Metabolites of Sinomenine Derivative 3a, Exerts Potent Anti-Aplastic Anemia Activity via IP3R/ORAI-Mediated CTL Ferroptosis. J Med Chem. 2025 Apr 17.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [2723569-00-2]