Ferroptosis inducer-7

CAT: 0804-HY-172803Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-172803Size:1 Each
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Description
Ferroptosis inducer-7 is an orally active and selective ferroptosis inducer via inositol 1,4,5-trisphosphate receptor (IP3R) /calcium release-activated calcium channel protein (ORAI) . Ferroptosis inducer-7 exhibits a notable effect in alleviating anemia symptoms, suppressing bone marrow CTLs activation, and improving hematopoietic function in immune-mediated bone marrow failure. Ferroptosis inducer-7 can be studied in research for aplastic anemia[1].
CAS Number
[2723569-00-2]
UNSPSC
12352005
Target
ERK; Ferroptosis; MEK; p38 MAPK
Related Pathways
Apoptosis; MAPK/ERK Pathway; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Smiles
O=C(/C=C/C1=CC=CC=C1)OC2=C3[C@]45[C@@](C=C(C(C5)=O)OC)([H])[C@](N(CC4)C)([H])CC3=C(C=C2OC)CO
Molecular Formula
C29H31NO6
Molecular Weight
489.56
References & Citations
[1]Zhang Z, et al., A Novel Compound 3a-M1, from Metabolites of Sinomenine Derivative 3a, Exerts Potent Anti-Aplastic Anemia Activity via IP3R/ORAI-Mediated CTL Ferroptosis. J Med Chem. 2025 Apr 17.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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