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FGFR4-IN-23

CAT: 0804-HY-172787Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-172787Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
FGFR4-IN-23 (compound 48c) is a FGFR4 inhibitor with an IC50 value of 2.9 nM against FGFR4WT kinase. FGFR4-IN-23 inhibits the phosphorylation of FGFR4, AKT and MAPK[1].
UNSPSC
12352101
Target
Akt; AMPK; FGFR
Related Pathways
Epigenetics; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
O=C(C1=C(NC(C=C)=O)C=C(N2CCN(C)CC2=O)C=C1F)NC3=NNC4=CC=C(O[C@H](C)C5=C(Cl)C=NC=C5Cl)C=C43
Molecular Formula
C29H26Cl2FN7O4
Molecular Weight
626.47
References & Citations
[1]Guo J, et al. Optimization of Aminoindazole derivatives as highly selective covalent inhibitors for wild-type and mutant FGFR4. Bioorg Chem. 2025 Jun 15;160:108469.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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