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Spore germination-IN-1

CAT: 0804-HY-172670-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-172670-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Spore germination-IN-1 (Compound 110) is an orally active spore germination inhibitor (IC50: 14 μM) . Spore germination-IN-1 specifically inhibits the enzymatic activities of mature SleC and CspB on spores (Kd: 12 and 8 μM) . Spore germination-IN-1 can be used in studies against C. difficile[1].
UNSPSC
12352005
Target
Fungal
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Concentration
10mM
Purity
98.67
Solubility
DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
FC(F)(F)C1=CC=C(C=C1)OC2=CC(C3=NOC(C4=CC=C(CN)C=C4)=N3)=CC=N2.Cl
Molecular Formula
C21H16ClF3N4O2
Molecular Weight
448.83
References & Citations
[1]Yang J, et al. Targeting SleC and CspB in the Inhibition of Spore Germination in Clostridioides difficile. J Med Chem. 2025 May 8;68 (9) :9357-9370.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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