Germination-IN-2

• Description:

  Germination-IN-2 (compound 15) is a potent germination inhibitor with an IC50 of 1.3 µM. Germination-IN-2 shows anti-germination activity with 3% germination rate[1].

• UNSPSC:

  12352005

• Target:

  Bacterial

• Type:

  Reference compound

• Related Pathways:

  Anti-infection

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/germination-in-2.html

• Solubility:

  10 mM in DMSO

• Smiles:

  C[C@@]12[C@](CC[C@]2([H])[C@H](C)CCC(NC3=CC=CC=C3)=O)([H])[C@@]4([H])[C@@](C[C@@H]1O)([H])[C@@]5([C@](C[C@@H](CC5)O)([H])CC4)C

• Molecular Formula:

  C30H45NO3

• Molecular Weight:

  467.68

• References & Citations:

  [1]Sharma SK, et al. Studies on the Importance of the 7α-, and 12α- hydroxyl groups of N-Aryl-3α,7α,12α-trihydroxy-5β-cholan-24-amides on their Antigermination Activity Against a Hypervirulent Strain of Clostridioides (Clostridium) difficile. Bioorg Med Chem. 2021 Dec 15;52:116503.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [89846-43-5]