SNX-0723

• Description :

  SNX-0723 is a potent Hsp90 Inhibitor with anti-Plasmodium activity. SNX-0723 shows high binding affinity for HsHsp90 and PfHsp90 with Kis of 4.4 and 47 nM, respectively. SNX-0723 inhibits liver-stage P. berghei ANKA parasites with the EC50 of 3.3 μM[1].

• UNSPSC :

  12352005

• Target :

  HSP; Parasite

• Type :

  Reference compound

• Related Pathways :

  Anti-infection; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

• Applications :

  COVID-19-anti-virus

• Field of Research :

  Infection

• Assay Protocol :

  https://www.medchemexpress.com/snx-0723.html

• Concentration :

  10mM

• Purity :

  99.12

• Solubility :

  DMSO : 20.83 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles :

  O=C(N)C1=C(N[C@@H]2COCC2)C=C(N3C=C(C)C4=C3CC(C)(C)CC4=O)C=C1F

• Molecular Formula :

  C22H26FN3O3

• Molecular Weight :

  399.46

• References & Citations :

  [1]Dora Posfai, et al. Identification of Hsp90 Inhibitors with Anti-Plasmodium Activity. Antimicrob Agents Chemother. 2018 Mar 27;62 (4) :e01799-17.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  Plasmodium

• CAS Number :

  [1073969-18-2]