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EGFR-IN-143

CAT: 0804-HY-172104Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-172104Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
EGFR-IN-143 (Compound 5f) is a potent EGFR inhibitor with an IC50 value of 0.15 μM. EGFR-IN-143 induces apoptosis by arresting the cell cycle in the G2/M phase. EGFR-IN-143 has antitumor activity[1].
UNSPSC
12352005
Target
Apoptosis; EGFR
Related Pathways
Apoptosis; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
CCCN1N=C(C(C(N/N=C\C2=CC=C(C(OC)=C2)O)=O)=N1)NC3=CC=C(C=C3)Cl
Molecular Formula
C20H21ClN6O3
Molecular Weight
428.87
References & Citations
[1]Nawareg NA, et al. Exploring 1,2,3-triazole-Schiff's base hybrids as innovative EGFR inhibitors for the treatment of breast cancer: In vitro and in silico study. Bioorg Chem. 2025 Jan 3;155:108106.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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