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DA-143

CAT: 0931-T200773-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T200773-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
PI3K, mTOR
Related Pathways
PI3K/Akt/mTOR signaling
Bioactivity
DA-143 is a selective inhibitor of DNA-PKcs (IC50: 2.5 nM), demonstrating disparate inhibitory effects on mTOR, PI3KΔ, and ATM, with IC50 values of 280 nM, 106 nM, and 6,594 nM, respectively. This compound effectively blocks the phosphorylation of DNA-PKcs substrates and enhances the sensitivity of cancer cells to doxorubicin.
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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