DA-143

• Target :

  PI3K|||mTOR

• Related Pathways :

  PI3K/Akt/mTOR signaling

• Bioactivity :

  DA-143 is a selective inhibitor of DNA-PKcs (IC50: 2.5 nM), demonstrating disparate inhibitory effects on mTOR, PI3K?, and ATM, with IC50 values of 280 nM, 106 nM, and 6,594 nM, respectively. This compound effectively blocks the phosphorylation of DNA-PKcs substrates and enhances the sensitivity of cancer cells to doxorubicin.

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C