BI-4659

CAT: 0804-HY-171878Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-171878Size:1 Each

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Description

BI-4659 (Compound 47i) is a TGF-β type I receptor (TGF-βRI) (Alk5) inhibitor with an IC50 of 19 nM. BI-4659 also inhibits (IC50: 99 nM) and significantly blocks TGFβRI-mediated phosphorylation of Smad2/3 with low cross-reactivities within the human kinome. BI-4659 can be used for fibrotic diseases like idiopathic pulmonary fibrosis (IPF) and cancers research[1].

CAS Number

894784-05-5

UNSPSC

12352005

Target

PDGFR; TGF-beta/Smad; TGF-β Receptor

Related Pathways

Protein Tyrosine Kinase/RTK; Stem Cell/Wnt; TGF-beta/Smad

Field of Research

Cancer; Inflammation/Immunology

Smiles

CN(C)CC(C=C1)=CC=C1N/C(C2=CC=CC=C2)=C3C4=CC=C(C(NCC)=O)C=C4NC/3=O

Molecular Formula

C27H28N4O2

Molecular Weight

440.54

References & Citations

[1]Roth GJ, et al. Design, synthesis, and evaluation of indolinones as inhibitors of the transforming growth factor β receptor I (TGFβRI) . J Med Chem. 2010 Oct 28;53 (20) :7287-95.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

ALK5; PDGFRα

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