QLS-81

• Description:

  QLS-81 is a Nav1.7 channel inhibitor (IC50: 1.5 μM) . QLS-81 has significant analgesic activity and can relieve neuropathic and inflammatory pain. QLS-81 exerts frequency-dependent inhibitory effects by inhibiting the inactivated state of Nav1.7 channels. QLS-81 can be used in the study of chronic pain[1].

• UNSPSC:

  12352005

• Target:

  Sodium Channel

• Related Pathways:

  Membrane Transporter/Ion Channel

• Field of Research:

  Inflammation/Immunology; Neurological Disease

• Smiles:

  C[C@H](NCCCC1=CC=C(OCC2=CC=CC=C2F)C=C1)C(N)=O

• Molecular Formula:

  C19H23FN2O2

• Molecular Weight:

  330.40

• References & Citations:

  [1]Niu HL, et al. Inhibition of Nav1.7 channel by a novel blocker QLS-81 for alleviation of neuropathic pain. Acta Pharmacol Sin. 2021 Aug;42 (8) :1235-1247.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [2835455-57-5]