Anticancer agent 81

• Description:

  Anticancer agent 81 (Compound 37b3) is an anticancer agent and can induce tumor cell cycle arrest and apoptosis. Anticancer agent 81 can be used as a payload to conjugate with Trastuzumab (HY-P9907) to obtain the antibody–agent conjugate (ADC) T-PBA. T-PBA maintained its mode of target and internalization ability of Trastuzumab[1].

• UNSPSC:

  12352203

• Target:

  ADC Payload; Apoptosis

• Type:

  ADC Related

• Related Pathways:

  Antibody-drug Conjugate/ADC Related; Apoptosis

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/anticancer-agent-81.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C1N (CCN2CCN (CCCCCOC3=C (OC) C=C4C (N=C[C@@] (CC (C5=CC=C (N) C=C5) =C6) ([H]) N6C4=O) =C3) CC2) C (C7=CC=CC8=CC9=CC=CC=C9C1=C78) =O

• Molecular Formula:

  C46H46N6O5

• Molecular Weight:

  762.89

• References & Citations:

  [1]Lai W, et al. Design, Synthesis, and Bioevaluation of a Novel Hybrid Molecular Pyrrolobenzodiazepine-Anthracenecarboxyimide as a Payload for Antibody-Drug Conjugate. J Med Chem. 2022 Aug 18.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  ADC Related

• Clinical Information:

  No Development Reported

• CAS Number:

  2820286-56-2