Products for Research Use Only
RegisterLogin

NLRP3-IN-81

CAT: 0804-HY-174312Size: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-174312Size:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
NLRP3-IN-81 (N102) is a BBB-penetrable inhibitor against NLRP3 inflammasome-dependent pyroptosis with an EC50 of 0.029 μM against cell pyroptosis induced by Nigericin. NLRP3-IN-81 potently inhibits NLRP3-dependent activation of caspase-1 and the release of IL-1β. NLRP3-IN-81 disturbs the interaction of NLRP3 with the adaptor protein ASC and inhibits ASC oligomerization. NLRP3-IN-81 can be used for pyroptosis-related diseases research, such as inflammatory bowel diseases and type 2 diabetes[1].
CAS Number
2922814-85-3
UNSPSC
12352005
Target
Caspase; Interleukin Related; NOD-like Receptor (NLR) ; Pyroptosis
Related Pathways
Apoptosis; Immunology/Inflammation
Field of Research
Inflammation/Immunology
Smiles
O=S(C1=NN=C(C=C1)C2=C(C=C(C=C2)C(F)(F)F)O)(C3CCCC3)=O
Molecular Formula
C16H15F3N2O3S
Molecular Weight
372.36
References & Citations
[1]Nan J, et al. Discovery and structure-activity relationship studies of 3-pyridazinesulfonyl derivatives as a new class of inhibitors against NLRP3 inflammasome-dependent pyroptosis. Eur J Med Chem. 2025 May 29;296:117796.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Caspase 1; IL-1; NLRP3

Related Products

CatalogName
HY-172788NLRP3-IN-78
HY-172102NLRP3-IN-68
HY-171820-01NLRP3-IN-80
HY-170233NLRP3-IN-75
HY-162901NLRP3-IN-48
HY-159719NLRP3-IN-51
HY-156469NLRP3-IN-22
HY-163300NLRP3-IN-30
HY-158111NLRP3-IN-34
HY-153261-01NLRP3-IN-17

Alternative Products

CatalogName
T210731-01NLRP3-IN-81
QY-E06005Human NLRP3 Inflammasome (NLRP3)
MBS8534011-01NLRP3
BA6124-10NLRP3-IN-17
BA6050-10NLRP3-IN-25

Popular Products