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CGS 24592

CAT: 0804-HY-171461Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-171461Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CGS 24592 is an orally active, selective and potent neutral endopeptidase 24.11 (NEP) inhibitor with an IC50 value of 1.6 nmol/L. CGS 24592 reduces the degradation of atrial natriuretic peptide (ANP), increases the concentration of ANP in the plasma, and reduces blood pressure. CGS 24592 is promising for research of cardiovascular disease, such as hypertension and congestive heart failure[1].
CAS Number
147923-04-4
UNSPSC
12352211
Target
Prolyl Endopeptidase (PREP)
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Smiles
OC(CCNC([C@@H](NCP(O)(O)=O)CC1=CC=C(C2=CC=CC=C2)C=C1)=O)=O
Molecular Formula
C19H23N2O6P
Molecular Weight
406.37
References & Citations
[1]Trapani AJ, et al. The pharmacology of CGS 25462: a potent, orally bioavailable, long-acting inhibitor of neutral endopeptidase 24.11. J Hypertens Suppl. 1993 Dec;11 (5) :S220-1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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