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Amyloid-β-IN-3

CAT: 0804-HY-171349-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-171349-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Amyloid-β-IN-3 (EX.113) is a selective γ-secretase inhibitor. Amyloid-β-IN-3 inhibits Aβ42 secretion in H4 cells with an EC50 value of 148 nM. Amyloid-β-IN-3 regulates the γ-secretase catalytic activity to decrease Aβ42 production, thereby alleviating neurotoxicity caused by Aβ deposition. Amyloid-β-IN-3 is promising for research of Alzheimer's disease (AD) [1].
CAS Number
1603833-56-2
UNSPSC
12352005
Target
Amyloid-β; γ-secretase
Related Pathways
Neuronal Signaling; Stem Cell/Wnt
Field of Research
Neurological Disease
Purity
99.50
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
FC1=CC(F)=CC(NC(C2=CC3=CC([C@H]4CN(CCC4)C(C)=O)=CC=C3N2)=O)=C1
Molecular Formula
C22H21F2N3O2
Molecular Weight
397.42
References & Citations
[1]Indol-amide compounds as beta-amyloid inhbitors. EP2722329A1. 2014-04-23.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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