Amyloid-β-IN-3

CAT: 0931-T207233-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0931-T207233-01Size:10 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

1603833-56-2

Target

Beta Amyloid, Gamma-secretase

Related Pathways

Neuroscience, Proteases/Proteasome, Stem Cells

Bioactivity

Amyloid-β-IN-3 (EX.113) is a selective inhibitor of γ-secretase. It demonstrates inhibitory activity on Aβ42 secretion in H4 cells, with an EC50 value of 148 nM. By modulating the catalytic activity of γ-secretase, Amyloid-β-IN-3 decreases Aβ42 production, thereby alleviating neurotoxicity caused by Aβ deposition. It holds potential for Alzheimer's disease (AD) research.

Smiles

C(NC1=CC(F)=CC(F)=C1)(=O)C2=CC=3C(N2)=CC=C(C3)[C@H]4CN(C(C)=O)CCC4

Molecular Formula

C22H21F2N3O2

Molecular Weight

397.42

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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HY-171349-01	Amyloid-β-IN-3
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Amyloid-β-IN-3

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