Amyloid-β-IN-2

CAT: 0804-HY-171348-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-171348-01Size:5 mg

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Description

Amyloid-β-IN-2 (Compound EX.112) is a selective γ-secretase inhibitor. Amyloid-β-IN-2 inhibits Aβ42 secretion in H4 cells with an EC50 value of 226 nM. Amyloid-β-IN-2 is promising for research of Alzheimer's disease (AD) and other diseases related to Aβ deposition[1].

CAS Number

1603833-55-1

UNSPSC

12352005

Target

Amyloid-β; γ-secretase

Related Pathways

Neuronal Signaling; Stem Cell/Wnt

Field of Research

Neurological Disease

Purity

99.47

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

FC1=CC(F)=CC(NC(C2=CC3=CC([C@@H]4CN(CCC4)C(C)=O)=CC=C3N2)=O)=C1

Molecular Formula

C22H21F2N3O2

Molecular Weight

397.42

References & Citations

[1]Indol-amide compounds as beta-amyloid inhbitors. EP2722329A1. 2014-04-23.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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Amyloid-β-IN-2

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