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PROTAC ROR1 degrader-1

CAT: 0804-HY-170995Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-170995Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PROTAC ROR1 degrader-1 (Compound 11d) is a PROTAC degrader for pseudokinase ROR1 that degrades ROR1 in NSCLC cells with a DC50s of 40-80 nM. PROTAC ROR1 degrader-1 causes the cleavage of PARP and induces apoptosis in NCI-H23[1]. (Pink: ligand for target protein ROR1 ligand-1 ; Black: linker (HY-W014787) ; Blue: ligand for VHL E3 ligase (S, R, S) -AHPC (HY-125845) )
UNSPSC
12352005
Target
Apoptosis; PROTACs; ROR
Related Pathways
Apoptosis; Metabolic Enzyme/Protease; PROTAC; Vitamin D Related/Nuclear Receptor
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
O=C([C@H]1N(C([C@@H](NC(CCCCCCCCC(N2CCN(C3=CC=C(C4=NC5=C(NC6CCN(CC)CC6)C(Br)=CN=C5N4)C=C3)CC2)=O)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC7=CC=C(C8=C(C)N=CS8)C=C7
Molecular Formula
C55H74BrN11O5S
Molecular Weight
1081.22
References & Citations
[1]Li J, et al., Discovery of the first potent ROR1 degrader for the treatment of non-small cell lung cancer. Eur J Med Chem. 2025 Mar 15;286:117325.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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