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MAO-B-IN-39

CAT: 0804-HY-170887Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-170887Size:1 Each
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Description
MAO-B-IN-39 (compound11) is a selective monoamine oxidase B (MAO-B) inhibitor. MAO-B-IN-39 inhibits MAO-Bwith an IC50 of 3.61 μM. MAO-B-IN-39 demonstrates a potent NRF2 induction capacity. MAO-B-IN-39 exhibits potent anti-inflammatory and neuroprotective activity in OS (oxidative stress) -related in vitro models. MAO-B-IN-39 demonstrates high liver microsomal stability and favorable pharmacokinetics in mice. MAO-B-IN-39 is potential for Parkinson’s disease (PD) research[1].
CAS Number
3094045-97-0
UNSPSC
12352005
Target
Keap1-Nrf2; Monoamine Oxidase
Related Pathways
Neuronal Signaling; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Smiles
O=C(NC1=CC=C2NC=CC2=C1)/C=C/C3=C(C=CC=C3)F
Molecular Formula
C17H13FN2O
Molecular Weight
280.30
References & Citations
[1]Zhang C, et al. Design, Synthesis, and Biological Evaluation of Chiral-Proline Derivatives as Novel HSP90 Inhibitors. ACS Med Chem Lett. 2025 Jan 22;16 (2) :301-310. |[2]Duarte P, et al. Network-Based Drug Optimization toward the Treatment of Parkinson's Disease: NRF2, MAO-B, Oxidative Stress, and Chronic Neuroinflammation. J Med Chem. 2025 Feb 13;68 (3) :3495-3517.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MAO-A; MAO-B

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