HNC-1664

• Description:

  HNC-1664 is the orally active inhibitor for RNA-dependent RNA polymerase (RdRP) . HNC-1664 exhibits broad-spectrum antiviral activity against coronavirus (SARS-CoV-2 wildtype and its mutants XBB.1.18, HK.3.1, BF.7.14, BA.1HCoV-229E, HCoV-OC43) and arenavirus. HNC-1664 exhibits anti-infectious activity in SARS-CoV-2 Delta infected mouse models[1].

• UNSPSC:

  12352005

• Target:

  Arenavirus; DNA/RNA Synthesis; SARS-CoV

• Related Pathways:

  Anti-infection; Cell Cycle/DNA Damage

• Field of Research:

  Infection

• Smiles:

  CC1=NC=NC2=C1C(I)=CN2[C@H]3[C@@H](F)[C@H](O)[C@@H](CO)O3

• Molecular Formula:

  C12H13FIN3O3

• Molecular Weight:

  393.15

• References & Citations:

  [1]Jia X, et al., An adenosine analog shows high antiviral potency against coronavirus and arenavirus mainly through an unusual base pairing mode. Nat Commun. 2024 Dec 30;15 (1) :10750.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [2127358-36-3]