CD73-IN-19

• Description :

  CD73-IN-19 (Compound 4ab) is a CD73 inhibitor (with a 44% inhibition rate of CD73 enzymatic activity at 100 μM) . CD73-IN-19 (at 10 μM and 100 μM) can completely antagonize the blockade of T cell proliferation induced by TCR (T cell receptor) triggering (which is induced by CD73 activity), and it can also inhibit the hA2A receptor activity in HEK-293 cells (Ki is 3.31 μM) . CD73-IN-19 holds promise for research in the field of immune diseases[1].

• CAS Number :

  [333329-22-9]

• UNSPSC :

  12352005

• Target :

  CD73

• Related Pathways :

  Immunology/Inflammation

• Field of Research :

  Inflammation/Immunology

• Smiles :

  O=C(C1=CC=C(NC(C2=C(N)C3=C(C)C=C(C)N=C3S2)=O)C=C1)OC

• Molecular Formula :

  C18H17N3O3S

• Molecular Weight :

  355.41

• References & Citations :

  [1]Grosjean F, et al. Third-Generation CD73 Inhibitors Based on a 4,6-Disubstituted-2-Thiopyridine Scaffold. ChemMedChem. 2024 Dec 13:e202400662.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported