MLK3-IN-1

• Description :

  MLK3-IN-1 (Compound 37) is a selective inhibitor for mixed-lineage protein kinase 3 (MLK3) with an IC50 FAK with an IC50 of 15.5 μM. MLK3-IN-1 exhibits good metabolic stability in mouse and human liver microsomes[1].

• UNSPSC :

  12352005

• Target :

  FAK; Mixed Lineage Kinase

• Related Pathways :

  MAPK/ERK Pathway; Protein Tyrosine Kinase/RTK

• Field of Research :

  Cancer

• Smiles :

  FC(C1=CC=C(NC2=NC=C(C(F)(F)F)C(NCC3=CC=CC(S(=O)(C)=O)=C3)=N2)C=C1)(F)F

• Molecular Formula :

  C20H16F6N4O2S

• Molecular Weight :

  490.42

• References & Citations :

  [1]Sander P, et al., Design, Synthesis, and Biochemical Evaluation of Novel MLK3 Inhibitors: A Target Hopping Example. J Med Chem. 2025 Jan 9;68 (1) :674-694.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported