MLK3-IN-1

CAT: 0804-HY-170486Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-170486Size:1 Each

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

MLK3-IN-1 (Compound 37) is a selective inhibitor for mixed-lineage protein kinase 3 (MLK3) with an IC50 FAK with an IC50 of 15.5 μM. MLK3-IN-1 exhibits good metabolic stability in mouse and human liver microsomes[1].

UNSPSC

12352005

Target

FAK; Mixed Lineage Kinase

Related Pathways

MAPK/ERK Pathway; Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Smiles

FC(C1=CC=C(NC2=NC=C(C(F)(F)F)C(NCC3=CC=CC(S(=O)(C)=O)=C3)=N2)C=C1)(F)F

Molecular Formula

C20H16F6N4O2S

Molecular Weight

490.42

References & Citations

[1]Sander P, et al., Design, Synthesis, and Biochemical Evaluation of Novel MLK3 Inhibitors: A Target Hopping Example. J Med Chem. 2025 Jan 9;68 (1) :674-694.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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