BCRP-IN-2

CAT: 0804-HY-169860-01Size: 1 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-169860-01Size:1 mg

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Description

BCRP-IN-2 has BCRP inhibitory activity and shows even greater inhibition of BCRP after activation by ultraviolet light. BCRP-IN-2 can be a valuable probe for studying the interactions of quinazolinamine derivatives with BCRP, as it stimulates ATP hydrolysis of the BCRP transport protein, increasing the accumulation of mitoxantrone in H460/MX20 cells with BCRP overexpression[1].

CAS Number

2953730-35-1

UNSPSC

12352005

Target

BCRP

Related Pathways

Membrane Transporter/Ion Channel

Field of Research

Cancer

Smiles

[N-]=[N+]=NC1=CC=C(NC2=NC(C3=CC=NC=C3)=NC4=CC=CC=C42)C=C1

Molecular Formula

C19H13N7

Molecular Weight

339.35

References & Citations

[1]Chao-Yun Cai, et al. Design, Synthesis and Biological Evaluation of Quinazolinamine Derivatives as Breast Cancer Resistance Protein and P-Glycoprotein Inhibitors with Improved Metabolic Stability. Biomolecules. 2023 Jan 30;13 (2) :253.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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