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PDIC-NN (dimethanesulfonate)

CAT: 0804-HY-169225ASize: 1 EachDry Ice: NoHazardous: No
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Description
PDIC-NN dimethanesulfonate (PDIC-NS) is a STING activator with anticancer activity. PDIC-NN dimethanesulfonate promotes the content and biostability of endogenous cyclic dinucleotides (CDNs) . PDIC-NN dimethanesulfonate triggers ROS burst and causes serious damage to mitochondria. PDIC-NN dimethanesulfonate induces cell apoptosis and inhibits DNA replication. PDIC-NN dimethanesulfonate activates cGAS-STING signaling pathway, enhances the immunogenicity of tumor cells and activates a robust innate immune response[1][2].
CAS Number
3040919-39-6
Product Name Alternative
PDIC-NS
UNSPSC
12352005
Target
Apoptosis; Reactive Oxygen Species (ROS) ; STING
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Field of Research
Cancer; Inflammation/Immunology
Smiles
O=C1N(C(C2=C(C3=C4C(Cl)=C2)C1=CC(Cl)=C3C5=C(C=C(C6=C7C=C(C4=C56)Cl)C(N(C7=O)CC[NH+](C)C)=O)Cl)=O)CC[NH+](C)C.CS(=O)([O-])=O.CS(=O)([O-])=O
Molecular Formula
C34H32Cl4N4O10S2
Molecular Weight
862.58
References & Citations
[1]Wang S, et al. Inhibition of human and rat placental 3β-hydroxysteroid dehydrogenases by bisphenol A analogues depends on their hydrophobicity: in silico docking analysis[J]. Chemico-Biological Interactions, 2024: 111251.|[2]Zhao X, et al. Sulfonated Perylene as Three-in-One STING Agonist for Cancer Chemo-Immunotherapy. Angew Chem Int Ed Engl. 2024 Mar 11;63 (11) :e202318799.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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