PDIC-NN (dimethanesulfonate)

• Description:

  PDIC-NN dimethanesulfonate (PDIC-NS) is a STING activator with anticancer activity. PDIC-NN dimethanesulfonate promotes the content and biostability of endogenous cyclic dinucleotides (CDNs) . PDIC-NN dimethanesulfonate triggers ROS burst and causes serious damage to mitochondria. PDIC-NN dimethanesulfonate induces cell apoptosis and inhibits DNA replication. PDIC-NN dimethanesulfonate activates cGAS-STING signaling pathway, enhances the immunogenicity of tumor cells and activates a robust innate immune response[1][2].

• Product Name Alternative:

  PDIC-NS

• UNSPSC:

  12352005

• Target:

  Apoptosis; Reactive Oxygen Species (ROS) ; STING

• Related Pathways:

  Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

• Field of Research:

  Cancer; Inflammation/Immunology

• Smiles:

  O=C1N(C(C2=C(C3=C4C(Cl)=C2)C1=CC(Cl)=C3C5=C(C=C(C6=C7C=C(C4=C56)Cl)C(N(C7=O)CC[NH+](C)C)=O)Cl)=O)CC[NH+](C)C.CS(=O)([O-])=O.CS(=O)([O-])=O

• Molecular Formula:

  C34H32Cl4N4O10S2

• Molecular Weight:

  862.58

• References & Citations:

  [1]Wang S, et al. Inhibition of human and rat placental 3β-hydroxysteroid dehydrogenases by bisphenol A analogues depends on their hydrophobicity: in silico docking analysis[J]. Chemico-Biological Interactions, 2024: 111251.|[2]Zhao X, et al. Sulfonated Perylene as Three-in-One STING Agonist for Cancer Chemo-Immunotherapy. Angew Chem Int Ed Engl. 2024 Mar 11;63 (11) :e202318799.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  3040919-39-6