NN-390

• Description:

  NN-390 is a potent and selective HDAC6 inhibitor, with an IC50 of 9.8 nM. NN-390 penetrates the blood-brain barrier (BBB) . NN-390 shows study potential in metastatic Group 3 MB (medulloblastoma) [1].

• UNSPSC:

  12352005

• Target:

  HDAC

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage; Epigenetics

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/nn-390.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(NO)C1=CC=C(CN(C(C)C)S(=O)(C2=CC(F)=C(F)C(F)=C2F)=O)C=C1

• Molecular Formula:

  C17H16F4N2O4S

• Molecular Weight:

  420.38

• References & Citations:

  [1]Nawar N, Bukhari S, Adile AA, et al. Discovery of HDAC6-Selective Inhibitor NN-390 with in Vitro Efficacy in Group 3 Medulloblastoma. J Med Chem. 2022;65 (4) :3193-3217.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  HDAC1; HDAC11; HDAC2; HDAC3; HDAC6; HDAC8

• CAS Number:

  2490284-25-6