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PDIC-NN

CAT: 0804-HY-169225-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-169225-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PDIC-NN (PDIC-NS free base) is a STING activator with anticancer activity. PDIC-NN promotes the content and biostability of endogenous cyclic dinucleotides (CDNs) . PDIC-NN triggers ROS burst and causes serious damage to mitochondria. PDIC-NN induces cell apoptosis and inhibits DNA replication. PDIC-NN activates cGAS-STING signaling pathway, enhances the immunogenicity of tumor cells and activates a robust innate immune response[1][2].
CAS Number
932740-48-2
Product Name Alternative
PDIC-NS (free base)
UNSPSC
12352005
Target
Apoptosis; Reactive Oxygen Species (ROS) ; STING
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/pdic-nn.html
Smiles
O=C1C2=CC(Cl)=C3C4=C(C=C5C(N(CCN(C)C)C(C6=CC(Cl)=C(C4=C56)C7=C3C2=C(C(N1CCN(C)C)=O)C=C7Cl)=O)=O)Cl
Molecular Formula
C32H24Cl4N4O4
Molecular Weight
670.37
References & Citations
[1]Wang S, et al. Inhibition of human and rat placental 3β-hydroxysteroid dehydrogenases by bisphenol A analogues depends on their hydrophobicity: in silico docking analysis[J]. Chemico-Biological Interactions, 2024: 111251.|[2]Zhao X, et al. Sulfonated Perylene as Three-in-One STING Agonist for Cancer Chemo-Immunotherapy. Angew Chem Int Ed Engl. 2024 Mar 11;63 (11) :e202318799.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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