ROS inducer 8

• Description :

  ROS inducer 8 (Compound 11g) is the inhibitor for glutathione (GSH), that induces the ROS accumulation in Enterococcus faecalis, thereby exhibiting antibacterial activity. ROS inducer 8 disrupts the biofilm, inhibits S. aureus and E. faecalis with MIC of 8 μg/mL and 2 μg/mL, exhibits post-antibiotic effect. ROS inducer 8 exhibits low hemolytic toxicity to sheep erythrocytes (HC50 > 1280 μg/mL) [1].

• UNSPSC :

  12352101

• Target :

  Bacterial; Reactive Oxygen Species (ROS)

• Related Pathways :

  Anti-infection; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

• Field of Research :

  Infection

• Smiles :

  CN(CC(N1CCN(C2=CC=C(N3C[C@H](CNC(C)=O)OC3=O)C=C2F)CC1)=O)CC4=CC=C([N+]([O-])=O)C=C4

• Molecular Formula :

  C26H31FN6O6

• Molecular Weight :

  542.56

• References & Citations :

  [1]Ampomah-Wireko M, et al., Design, synthesis and antibacterial evaluation of oxazolidinone derivatives containing N-methylglycyl or quaternary ammonium salts. Bioorg Med Chem. 2025 Mar 2;122:118144.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported