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DP-15

CAT: 0804-HY-168936-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-168936-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DP-15 is the degrader for GSPT1 and BRD4 with DC50s of 5.25 nM and 0.48 nM. DP-15 exhibits anti-proliferative activity of AML cells and NHL cells with an IC50 of nanomolar levels, arrests the cell cycle at G1 phase, and induces apoptosis in MOLM13. DP-15 exhibits anti-leukemia activity in MOLM-13 xenograft mouse models[1]. (Pink: ligand for target protein JQ-1 carboxylic acid ; Black: linker (HY-W262798) ; Blue: ligand for E3 ligase Cereblon Thalidomide-5-OH (HY-23095) )
CAS Number
3033837-71-4
UNSPSC
12352005
Target
Apoptosis; Epigenetic Reader Domain; PROTACs
Related Pathways
Apoptosis; Epigenetics; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
CC1=C(C)SC2=C1C(C3=CC=C(C=C3)Cl)=N[C@@H](CC(N4CCN(CC4)CC5CCN(C6=CC=C(C(N(C7C(NC(CC7)=O)=O)C8=O)=O)C8=C6)CC5)=O)C9=NN=C(C)N29
Molecular Formula
C42H44ClN9O5S
Molecular Weight
822.37
References & Citations
[1]Xu Y, et al., Discovery of highly potent dual GSPT1/BRD4 degraders with anti-AML activity. Eur J Med Chem. 2025 Apr 15;288:117381.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

CID 171476753
CAS Number3033837-71-4
PubChem CID171476753
IUPAC Name5-[4-[[4-[2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]acetyl]piperazin-1-yl]methyl]piperidin-1-yl]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione
Molecular FormulaC42H44ClN9O5S
Molecular Weight822.4
XLogP4.1
Topological Polar Surface Area182
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count11
Rotatable Bond Count7
Heavy Atom Count58
Formal Charge0
Complexity1650
SMILES
CC1=C(SC2=C1C(=N[C@H](C3=NN=C(N32)C)CC(=O)N4CCN(CC4)CC5CCN(CC5)C6=CC7=C(C=C6)C(=O)N(C7=O)C8CCC(=O)NC8=O)C9=CC=C(C=C9)Cl)C
InChI
InChI=1S/C42H44ClN9O5S/c1-23-24(2)58-42-36(23)37(27-4-6-28(43)7-5-27)44-32(38-47-46-25(3)51(38)42)21-35(54)50-18-16-48(17-19-50)22-26-12-14-49(15-13-26)29-8-9-30-31(20-29)41(57)52(40(30)56)33-10-11-34(53)45-39(33)55/h4-9,20,26,32-33H,10-19,21-22H2,1-3H3,(H,45,53,55)/t32-,33?/m0/s1
InChIKey
NQXAVWUIYCADSJ-JEFWXSHNSA-N
Chemical Structure
2D Structure
2D structure of CID 171476753
CAS: 3033837-71-4
CID: 171476753
Formula: C42H44ClN9O5S
MW: 822.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight822.4
XLogP34.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count11
Rotatable Bond Count7
Exact Mass821.2874644
Monoisotopic Mass821.2874644
Topological Polar Surface Area182 Ų
Heavy Atom Count58
Formal Charge0
Complexity1650
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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