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PMEG-DP (disodium)

CAT: 0804-HY-164018ASize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-164018ASize:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PMEG-DP disodium is a potent DNA polymerase inhibitor (IC50=2.5 μM), especially for DNA polymerase α and δ. PMEG-DP disodium acts as an active metabolite of G-9191, which effectively inhibits the growth of papillomavirus (HPV) -infected cell lines. PMEG-DP disodium can be used in the study of HPV-related diseases[1].
UNSPSC
12352005
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/pmeg-dp-disodium.html
Smiles
O=C1N=C(NC2=C1N=CN2CCOCP(O)(OP(O)(OP(O[Na])(O[Na])=O)=O)=O)N
Molecular Formula
C8H12N5Na2O11P3
Molecular Weight
493.11
References & Citations
[1]Wolfgang G H I, et al. GS-9191 is a novel topical prodrug of the nucleotide analog 9- (2-phosphonylmethoxyethyl) guanine with antiproliferative activity and possible utility in the treatment of human papillomavirus lesions[J]. Antimicrobial agents and chemotherapy, 2009, 53 (7) : 2777-2784.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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