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DP-C-4

CAT: 0804-HY-141481-01Size: 5 mgDry Ice: YesHazardous: No
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CAT#:0804-HY-141481-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DP-C-4 is a Cereblon-based dual PROTAC for simultaneous degradation of EGFR and PARP[1].
UNSPSC
12352005
Target
EGFR; PARP; PROTACs
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; JAK/STAT Signaling; PROTAC; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dp-c-4.html
Purity
98.15
Solubility
DMSO : 12 mg/mL (ultrasonic)
Smiles
O=C1NN=C(CC2=CC=C(F)C(C(N3CCN(C(CCCCCNC(C(NC(CCCCCOC4=C(OC)C=C(N=CN=C5NC6=CC=C(F)C(Cl)=C6)C5=C4)=O)COCC7=CN(CCOCCOCCNC8=CC=CC(C(N9C%10CCC(NC%10=O)=O)=O)=C8C9=O)N=N7)=O)=O)CC3)=O)=C2)C%11=C1C=CC=C%11
Molecular Formula
C72H78ClF2N15O14
Molecular Weight
1450.93
References & Citations
[1]Mengzhu Zheng, et al. Rational Design and Synthesis of Novel Dual PROTACs for Simultaneous Degradation of EGFR and PARP. J Med Chem. 2021 May 26.
Shipping Conditions
Dry Ice
Storage Conditions
-80°C, stored under nitrogen
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon

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