DP-C-4

• Description :

  DP-C-4 is a Cereblon-based dual PROTAC for simultaneous degradation of EGFR and PARP[1].

• UNSPSC :

  12352005

• Target :

  EGFR; PARP; PROTACs

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage; Epigenetics; JAK/STAT Signaling; PROTAC; Protein Tyrosine Kinase/RTK

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/dp-c-4.html

• Purity :

  98.15

• Solubility :

  DMSO : 12 mg/mL (ultrasonic)

• Smiles :

  O=C1NN=C(CC2=CC=C(F)C(C(N3CCN(C(CCCCCNC(C(NC(CCCCCOC4=C(OC)C=C(N=CN=C5NC6=CC=C(F)C(Cl)=C6)C5=C4)=O)COCC7=CN(CCOCCOCCNC8=CC=CC(C(N9C%10CCC(NC%10=O)=O)=O)=C8C9=O)N=N7)=O)=O)CC3)=O)=C2)C%11=C1C=CC=C%11

• Molecular Formula :

  C72H78ClF2N15O14

• Molecular Weight :

  1450.93

• References & Citations :

  [1]Mengzhu Zheng, et al. Rational Design and Synthesis of Novel Dual PROTACs for Simultaneous Degradation of EGFR and PARP. J Med Chem. 2021 May 26.

• Shipping Conditions :

  Dry Ice

• Storage Conditions :

  -80°C, stored under nitrogen

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  Cereblon