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Anti-inflammatory agent 95

CAT: 0804-HY-168935Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-168935Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Anti-inflammatory agent 95 (Compound 2e) is an anti-inflammatory agent that exhibits the most potent anti-inflammatory activity in LPS -induced RAW 264.7 mouse macrophages. It significantly inhibits the production of NO, with an IC50 of 8.8 μM, and reduces the secretion of TNF-α and IL-1β, with inhibition rates reaching 60% and over 90%, respectively, at a concentration of 100 μM. Anti-inflammatory agent 95 holds promise for research in the field of inflammatory diseases[1].
UNSPSC
12352005
Target
Interleukin Related; NO Synthase; TNF Receptor
Related Pathways
Apoptosis; Immunology/Inflammation
Field of Research
Inflammation/Immunology
Smiles
[H][C@@]12OC(N3CCC=C([C@]32[H])/C([C@@H]1OC(CCCC)=O)=C/C)=O
Molecular Formula
C16H21NO4
Molecular Weight
291.34
References & Citations
[1]Lu S, et al. Design, synthesis and biological evaluation of Streptazolin analogs as anti-inflammatory agents. Bioorg Med Chem Lett. 2025 Feb 14;120:130139.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IL-1

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