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Anti-inflammatory agent 22

CAT: 0804-HY-146435Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-146435Size:1 Each
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Description
Anti-inflammatory agent 22 (compound 14a) is an orally active anti-inflammatory agent. Anti-inflammatory agent 22 inhibits LPS-induced TNF-α production with an IC50 value of 14.6 μM. Anti-inflammatory agent 22 has preventive effects on lymphedematous tissue via suppression of adipogenesis. Anti-inflammatory agent 22 suppresses limb lymphedema volume in mice[1].
CAS Number
2721484-76-8
UNSPSC
12352005
Target
TNF Receptor
Type
Reference compound
Related Pathways
Apoptosis
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/anti-inflammatory-agent-22.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=C(C=C(C=C1)O)OC(C2=CC=CC=C2)=O)/C=C/C3=CC=C(C(O)=C3)O
Molecular Formula
C22H16O6
Molecular Weight
376.36
References & Citations
[1]Roh K, et al. Synthesis and evaluation of butein derivatives for in vitro and in vivo inflammatory response suppression in lymphedema. Eur J Med Chem. 2020;197:112280.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TNFRSF5/CD40

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