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TRF2-IN-1

CAT: 0804-HY-168890Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-168890Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TRF2-IN-1 (compound F2) is a potent telomere repeat-binding factor 2 (TRF2) inhibitor. TRF2-IN-1 shows antiproliferative activity. TRF2-IN-1 induces apoptosis. TRF2-IN-1 directly bind to the TRF2TRFH domain and selectively inhibits TRF2 protein expression and telomeric localization. TRF2-IN-1 shows anticancer activity. TRF2-IN-1 has the potential for the research of osteosarcoma[1].
UNSPSC
12352101
Target
Apoptosis; Telomerase
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Field of Research
Cancer
Smiles
O=C(/C=C/C1=CC=CC(Br)=C1)C2=C(OC)C=C(OC)C=C2OC
Molecular Formula
C18H17BrO4
Molecular Weight
377.23
References & Citations
[1]Wang K, et al. Design, synthesis, and biological evaluation of Flavokavain B derivatives as potent TRF2 inhibitors for the treatment of Osteosarcoma. Eur J Med Chem. 2025 Mar 15;286:117279.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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