TRF2-IN-1

• Description :

  TRF2-IN-1 (compound F2) is a potent telomere repeat-binding factor 2 (TRF2) inhibitor. TRF2-IN-1 shows antiproliferative activity. TRF2-IN-1 induces apoptosis. TRF2-IN-1 directly bind to the TRF2TRFH domain and selectively inhibits TRF2 protein expression and telomeric localization. TRF2-IN-1 shows anticancer activity. TRF2-IN-1 has the potential for the research of osteosarcoma[1].

• UNSPSC :

  12352101

• Target :

  Apoptosis; Telomerase

• Related Pathways :

  Apoptosis; Cell Cycle/DNA Damage

• Field of Research :

  Cancer

• Smiles :

  O=C(/C=C/C1=CC=CC(Br)=C1)C2=C(OC)C=C(OC)C=C2OC

• Molecular Formula :

  C18H17BrO4

• Molecular Weight :

  377.23

• References & Citations :

  [1]Wang K, et al. Design, synthesis, and biological evaluation of Flavokavain B derivatives as potent TRF2 inhibitors for the treatment of Osteosarcoma. Eur J Med Chem. 2025 Mar 15;286:117279.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported