TRFS-green

• Description :

  TRFS-green is a highly selective off−on fluorescent probe for imaging selenoprotein thioredoxin reductase (TrxR) in living cells. TRFS-green has the maximum absorbance at around 373 nm. After it is activated by TrxR, the maximum absorbance shifts to around 440 nm[1].

• CAS Number :

  [1513848-14-0]

• UNSPSC :

  12352005

• Target :

  TrxR

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Field of Research :

  Others

• Assay Protocol :

  https://www.medchemexpress.com/trfs-green.html

• Concentration :

  10mM

• Purity :

  97.0

• Solubility :

  DMSO : 25 mg/mL (ultrasonic)

• Smiles :

  O=C(OC1CSSC1)NC2=CC=C(C3=C4C=CC=C32)C(N(CCCC)C4=O)=O

• Molecular Formula :

  C20H20N2O4S2

• Molecular Weight :

  416.51

• References & Citations :

  [1]Liangwei Zhang, et al. Highly selective off-on fluorescent probe for imaging thioredoxin reductase in living cells. J Am Chem Soc. 2014 Jan 8;136 (1) :226-33.|[2]Xinming Li, et al. A fast and specific fluorescent probe for thioredoxin reductase that works via disulphide bond cleavage. Nat Commun. 2019 Jun 21;10 (1) :2745.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported