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TP-TRFS

CAT: 0804-HY-D1253Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-D1253Size:1 Each
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Description
TP-TRFS is a highly selective and the first two-photon fluorescent probe of thioredoxin reductase (TrxR) [1].
CAS Number
2937819-61-7
UNSPSC
12352005
Target
TrxR
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/tp-trfs.html
Solubility
10 mM in DMSO
Smiles
CC(C1=CC=C2C=C(C=CC2=C1)NC(OC3CSSC3)=O)=O
Molecular Formula
C16H15NO3S2
Molecular Weight
333.43
References & Citations
[1]Jintao Zhao, et al. Loss of thioredoxin reductase function in a mouse stroke model disclosed by a two-photon fluorescent probe. Chem Commun (Camb) . 2020 Nov 12;56 (90) :14075-14078.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

TP-Trfs
CAS Number2937819-61-7
PubChem CID162642072
IUPAC Namedithiolan-4-yl N-(6-acetylnaphthalen-2-yl)carbamate
Molecular FormulaC16H15NO3S2
Molecular Weight333.4
XLogP3
Topological Polar Surface Area106
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Heavy Atom Count22
Formal Charge0
Complexity426
SMILES
CC(=O)C1=CC2=C(C=C1)C=C(C=C2)NC(=O)OC3CSSC3
InChI
InChI=1S/C16H15NO3S2/c1-10(18)11-2-3-13-7-14(5-4-12(13)6-11)17-16(19)20-15-8-21-22-9-15/h2-7,15H,8-9H2,1H3,(H,17,19)
InChIKey
XAGJAVLIKPWKQV-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of TP-Trfs
CAS: 2937819-61-7
CID: 162642072
Formula: C16H15NO3S2
MW: 333.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight333.4
XLogP33
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Exact Mass333.04933569
Monoisotopic Mass333.04933569
Topological Polar Surface Area106 Ų
Heavy Atom Count22
Formal Charge0
Complexity426
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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