Products for Research Use Only
RegisterLogin

Enpp-1-IN-25

CAT: 0804-HY-168491Size: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-168491Size:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Enpp-1-IN-25 (Compound 30) is an ENPP1 inhibitor with an IC50 of 8.05 nM and low oral bioavailability. Enpp-1-IN-25 can effectively activate the intracellular STING pathway by inhibiting cGAMP degradation. Enpp-1-IN-25 can enhance immune cell infiltration in the tumor microenvironment and type I interferon responses, and potentiate the antitumor efficacy of the anti-PD-L1 antibody. Enpp-1-IN-25 can be used in the research of cancer immunotherapy[1].
CAS Number
3067908-20-4
UNSPSC
12352005
Target
PD-1/PD-L1; Phosphodiesterase (PDE) ; STING
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease
Field of Research
Cancer
Smiles
COC1=C(C2=CC=C1)N=CN=C2N3CCC(CNS(=O)(N)=O)(CC3)O
Molecular Formula
C15H21N5O4S
Molecular Weight
367.42
References & Citations
[1]He J, et al. Design, Synthesis, and Pharmacological Evaluation of Quinazoline and Quinoline Derivatives as Potent ENPP1 Inhibitors for Cancer Immunotherapy. J Med Chem. 2025 Feb 20.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-129490-01Enpp-1-IN-1
HY-145064Enpp-1-IN-6
HY-145063-01Enpp-1-IN-5
HY-155457-01Enpp-1-IN-19
HY-147389-01Enpp-1-IN-14
HY-153335-01Enpp-1-IN-16
HY-175478Enpp-1-IN-27
HY-145069Enpp-1-IN-8
HY-147998Enpp-1-IN-13
HY-153334Enpp-1-IN-15

Alternative Products

CatalogName
GTR19250335-01Enpp-1-IN-25
BA8150-5Enpp-1-IN-1
BA8190-10Enpp-1-IN-16
BA6275-10Enpp-1-IN-19
BA8220-1Enpp-1-IN-5
BA8154-25Enpp-1-IN-14
T75126-01Enpp-1-IN-15

Popular Products