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Enpp-1-IN-27

CAT: 0804-HY-175478Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-175478Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Enpp-1-IN-27 is a selective ENPP1 inhibitor with an IC50 of 14.68 nM, exhibiting approximately 410-fold selectivity against ENPP2 and 10-fold selectivity against ENPP3. Enpp-1-IN-27 stabilizes cGAMP levels and activates the STING pathway, promoting cytokine release and enhancing innate immune responses. Enpp-1-IN-27 induces ISRE activation and amplified cGAMP-mediated immune responses and shows the desired antitumor efficacy in the 4T1 and CT26 syngeneic mouse models. Enpp-1-IN-27 can used for the studies of breast cancer and colon cancer[1].
CAS Number
3105103-33-8
UNSPSC
12352005
Target
Phosphodiesterase (PDE) ; STING
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Smiles
O=C1NC(N=CN=C2N3CCC(CNS(N)(=O)=O)(CC3)CCl)=C2C1
Molecular Formula
C13H19ClN6O3S
Molecular Weight
374.85
References & Citations
[1]Ji SH, et al. Identification of 5,7-Dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one Derivatives as ENPP1 Inhibitors for STING Pathway-Mediated Immunotherapy. J Med Chem. 2025 Aug 14;68 (15) :16059-16075.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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