Products for Research Use Only
RegisterLogin

PROTAC WDR5 degrader 1

CAT: 0804-HY-168487-01Size: 1 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-168487-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
PROTAC WDR5 degrader 1 (compound 8g) is a PROTAC degrader targeting WDR5. PROTAC WDR5 degrader 1 is composed of a target protein ligand (red part) WDR5 ligand 2 , a VHL-type E3 ligase ligand (blue part) (S, R, S) -AHPC (HY-125845), and a PROTAC linker (balck part) 5-Aminovaleric acid (HY-W015878), in which the VHL ligand and the PROTAC linker form a conjugate (HY-114176A).
CAS Number
2737222-94-3
UNSPSC
12352005
Target
DNA/RNA Synthesis; PROTACs; WDR5
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Others
Smiles
O=C(C(C(C(F)(F)F)=C1)=CNC1=O)NC2=C(N3CCN(CC3)C)C=CC(C4=CC=C(C=C4)C(NCCCCC(N[C@@H](C(C)(C)C)C(N5[C@@H](C[C@H](C5)O)C(NCC6=CC=C(C7=C(C)N=CS7)C=C6)=O)=O)=O)=O)=C2
Molecular Formula
C52H60F3N9O7S
Molecular Weight
1012.15
References & Citations
[1]Dölle A, et al. Design, Synthesis, and Evaluation of WD-Repeat-Containing Protein 5 (WDR5) Degraders. J Med Chem. 2021 Aug 12;64 (15) :10682-10710.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-162014-01WDR5 degrader-1
HY-178034PROTAC OSBP Degrader-1
HY-176857-01PROTAC STAT6 degrader-1
HY-175830PROTAC AURKA degrader 1
HY-175358PROTAC USP7 Degrader-1
HY-173135PROTAC KDM4 degrader-1
HY-172208-01PROTAC cGAS degrader-1
HY-163897-01PROTAC NCOA4 degrader-1
HY-163609PROTAC AKR1C3 degrader-1
HY-163938-01PROTAC erf3a Degrader-1

Alternative Products

CatalogName
T208803-01WDR5 degrader-1
T13845PROTAC PARP1 degrader
JFC27550-01PROTAC cIAP1 degrader-4
T74602-01PROTAC EZH2 Degrader-1
T18604PROTAC CRBN Degrader-1
T212207-01PROTAC BET Degrader-13
T211940-01PROTAC BRD4 Degrader-37
T211884-01PROTAC IRAK4 degrader-13
T211537-01PROTAC BRD4 Degrader-38
T211533-01PROTAC BRD4 Degrader-36

Popular Products