WDR5 degrader-1

WDR5 degrader-1

• CAS Number: 3032434-45-7
• UNSPSC Description: WDR5 degrader-1 (compound 25) is a cereblon (CRBN)-recruiting WDR5 degrader. WDR5 degrader-1 selectively degraded WDR5 over the CRBN neo-substrate IKZF1[1].
• Target Antigen: PROTACs
• Type: Reference compound
• Related Pathways: PROTAC
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/wdr5-degrader-1.html
• Solubility: DMSO : 100 mg/mL (ultrasonic)
• Smiles: CN1[C@@H](CN(C2=C(C=C(C=C2)C3=CC(C(NCCCCCCCNC(COC4=C(C5=CC=C4)C(N(C5=O)C6C(NC(CC6)=O)=O)=O)=O)=O)=CC=C3F)NC(C7=CNC(C=C7C(F)(F)F)=O)=O)C[C@@H]1C)C
• Molecular Weight: 972.98
• References & Citations: [1]Xufen Yu, et al. Discovery of Potent and Selective WDR5 Proteolysis Targeting Chimeras as Potential Therapeutics for Pancreatic Cancer. J Med Chem. 2023, 66, 23.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported