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CLIK-148

CAT: 0013-GTR19273496-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19273496-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CLIK-148 is an oral, highly selective, irreversible inhibitor of cysteine protease that primarily targets cathepsin L. It effectively impedes the cathepsin L-dependent degradation of HMG-CoA reductase on the endoplasmic reticulum (ER) membrane. Additionally, CLIK-148 inhibits the cathepsin L-mediated processing of procholecystokinin (proCCK), leading to reduced production of CCK8. By obstructing cathepsin L degradation of type I collagen secreted by osteoclasts, CLIK-148 decreases tumor-induced bone metastasis and malignant hypercalcemia. This compound is valuable for research into bone metabolism disorders and neuropeptide processing regulation.
CAS Number
215098-90-1
Smiles
C (N[C@@H] (CC1=CC=CC=C1) C (N (C) C) =O) (=O) [C@@H]2[C@@H] (C (NCCC3=CC=CC=N3) =O) O2
Molecular Formula
C22H26N4O4
Molecular Weight
410.47
Storage Conditions
-20°C
Notes
For research use only.

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