ISO-1 (Standard)

• Description:

  ISO-1 (Standard) is the analytical standard of ISO-1. This product is intended for research and analytical applications. ISO-1 is a macrophage migration inhibitory factor (MIF) antagonist with an IC50 of 7 μM.

• UNSPSC:

  12352100

• Target:

  Macrophage migration inhibitory factor (MIF) ; Reference Standards

• Related Pathways:

  Immunology/Inflammation; Others

• Field of Research:

  Inflammation/Immunology

• Smiles:

  O=C(OC)CC1ON=C(C(C=C2)=CC=C2O)C1

• Molecular Formula:

  C12H13NO4

• Molecular Weight:

  235.24

• References & Citations:

  [1]Lubetsky JB, et al. The tautomerase active site of macrophage migration inhibitory factor is a potential target for discovery of novel anti-inflammatory agents. J Biol Chem. 2002 Jul 12;277 (28) :24976-82.|[2]Al-Abed Y, et al. ISO-1 binding to the tautomerase active site of MIF inhibits its pro-inflammatory activity and increases survival in severe sepsis. J Biol Chem. 2005 Nov 4;280 (44) :36541-4.|[3]Nothnick WB, et al. Inhibition of macrophage migration inhibitory factor reduces endometriotic implant size in mice with experimentally induced disease. J Endometr. 2011 Sep 30;3 (3) :135-142.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference Standards

• CAS Number:

  478336-92-4