Iso-OMPA

• Description:

  Iso-OMPA (Tetraisopropyl pyrophosphoramide) is a selective inhibitor of the irreversible butyrylcholinesterase (BuChE) . Iso-OMPA enhances soman toxicity in rats associated with the inhibition of plasma carboxylesterase (CarbE) [1][2][3].

• Product Name Alternative:

  Tetraisopropyl pyrophosphoramide

• UNSPSC:

  12352211

• Hazard Statement:

  H300+H310+H330

• Target:

  Cholinesterase (ChE)

• Type:

  Reference compound

• Related Pathways:

  Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/iso-ompa.html

• Concentration:

  10mM

• Purity:

  99.90

• Solubility:

  DMSO : 100 mg/mL (ultrasonic) |H2O : 10 mg/mL (ultrasonic)

• Smiles:

  O=P(NC(C)C)(NC(C)C)OP(NC(C)C)(NC(C)C)=O

• Molecular Formula:

  C12H32N4O3P2

• Molecular Weight:

  342.36

• Precautions:

  H300+H310+H330

• References & Citations:

  [1]Rodríguez-Fuentes G, et al. Characterization of cholinesterase activity from different tissues of Nile tilapia (Oreochromis niloticus) . Mar Environ Res. 2004 Aug-Dec;58 (2-5) :505-9.|[2]Z Grubic, et al. Iso-OMPA-induced potentiation of soman toxicity in rat correlates with the inhibition of plasma carboxylesterases. Arch Toxicol. 1988;62 (5) :398-9.|[3]X Norel, et al. Degradation of acetylcholine in human airways: role of butyrylcholinesterase. Br J Pharmacol. 1993 Apr;108 (4) :914-9.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [513-00-8]