Iso-OMPA

CAT: 0804-HY-131922-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-131922-01Size:5 mg
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Description
Iso-OMPA (Tetraisopropyl pyrophosphoramide) is a selective inhibitor of the irreversible butyrylcholinesterase (BuChE) . Iso-OMPA enhances soman toxicity in rats associated with the inhibition of plasma carboxylesterase (CarbE) [1][2][3].
CAS Number
[513-00-8]
Product Name Alternative
Tetraisopropyl pyrophosphoramide
UNSPSC
12352211
Hazard Statement
H300+H310+H330
Target
Cholinesterase (ChE)
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/iso-ompa.html
Concentration
10mM
Purity
99.90
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : 10 mg/mL (ultrasonic)
Smiles
O=P(NC(C)C)(NC(C)C)OP(NC(C)C)(NC(C)C)=O
Molecular Formula
C12H32N4O3P2
Molecular Weight
342.36
Precautions
H300+H310+H330
References & Citations
[1]Rodríguez-Fuentes G, et al. Characterization of cholinesterase activity from different tissues of Nile tilapia (Oreochromis niloticus) . Mar Environ Res. 2004 Aug-Dec;58 (2-5) :505-9.|[2]Z Grubic, et al. Iso-OMPA-induced potentiation of soman toxicity in rat correlates with the inhibition of plasma carboxylesterases. Arch Toxicol. 1988;62 (5) :398-9.|[3]X Norel, et al. Degradation of acetylcholine in human airways: role of butyrylcholinesterase. Br J Pharmacol. 1993 Apr;108 (4) :914-9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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