ISO-1

• Description:

  ISO-1 is a macrophage migration inhibitory factor (MIF) antagonist with an IC50 of 7 μM.

• Product Name Alternative:

  MIF Antagonist

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Macrophage migration inhibitory factor (MIF)

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/ISO-1.html

• Concentration:

  10mM

• Purity:

  99.94

• Solubility:

  DMSO : 50 mg/mL (ultrasonic) |Ethanol : 100 mg/mL (ultrasonic)

• Smiles:

  O=C(OC)CC1ON=C(C(C=C2)=CC=C2O)C1

• Molecular Formula:

  C12H13NO4

• Molecular Weight:

  235.24

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Lubetsky JB, et al. The tautomerase active site of macrophage migration inhibitory factor is a potential target for discovery of novel anti-inflammatory agents. J Biol Chem. 2002 Jul 12;277 (28) :24976-82.|[2]Al-Abed Y, et al. ISO-1 binding to the tautomerase active site of MIF inhibits its pro-inflammatory activity and increases survival in severe sepsis. J Biol Chem. 2005 Nov 4;280 (44) :36541-4.|[3]Nothnick WB, et al. Inhibition of macrophage migration inhibitory factor reduces endometriotic implant size in mice with experimentally induced disease. J Endometr. 2011 Sep 30;3 (3) :135-142.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 1

• CAS Number:

  478336-92-4