ISO-1
CAT:
804-HY-16692-04
Size:
50 mg
Price:
Ask
- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No

ISO-1
- CAS Number: 478336-92-4
- UNSPSC Description: ISO-1 is a macrophage migration inhibitory factor (MIF) antagonist with an IC50 of 7 μM.
- Target Antigen: Macrophage migration inhibitory factor (MIF)
- Type: Reference compound
- Related Pathways: Immunology/Inflammation
- Applications: COVID-19-immunoregulation
- Field of Research: Inflammation/Immunology
- Assay Protocol: https://www.medchemexpress.com/ISO-1.html
- Solubility: DMSO : 50 mg/mL (ultrasonic)|Ethanol : 100 mg/mL (ultrasonic)
- Smiles: O=C(OC)CC1ON=C(C(C=C2)=CC=C2O)C1
- Molecular Weight: 235.24
- References & Citations: [1]Lubetsky JB, et al. The tautomerase active site of macrophage migration inhibitory factor is a potential target for discovery of novel anti-inflammatory agents. J Biol Chem. 2002 Jul 12;277(28):24976-82.|[2]Al-Abed Y, et al. ISO-1 binding to the tautomerase active site of MIF inhibits its pro-inflammatory activity and increases survival in severe sepsis. J Biol Chem. 2005 Nov 4;280(44):36541-4.|[3]Nothnick WB, et al. Inhibition of macrophage migration inhibitory factor reduces endometriotic implant size in mice with experimentally induced disease. J Endometr. 2011 Sep 30;3(3):135-142.
- Shipping Conditions: Room Temperature
- Clinical Information: Phase 1