ISO-1

• UNSPSC Description:

  ISO-1 is a macrophage migration inhibitory factor (MIF) antagonist with an IC50 of 7 μM.

• Target Antigen:

  Macrophage migration inhibitory factor (MIF)

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/ISO-1.html

• Solubility:

  DMSO : 50 mg/mL (ultrasonic)|Ethanol : 100 mg/mL (ultrasonic)

• Smiles:

  O=C(OC)CC1ON=C(C(C=C2)=CC=C2O)C1

• Molecular Weight:

  235.24

• References & Citations:

  [1]Lubetsky JB, et al. The tautomerase active site of macrophage migration inhibitory factor is a potential target for discovery of novel anti-inflammatory agents. J Biol Chem. 2002 Jul 12;277(28):24976-82.|[2]Al-Abed Y, et al. ISO-1 binding to the tautomerase active site of MIF inhibits its pro-inflammatory activity and increases survival in severe sepsis. J Biol Chem. 2005 Nov 4;280(44):36541-4.|[3]Nothnick WB, et al. Inhibition of macrophage migration inhibitory factor reduces endometriotic implant size in mice with experimentally induced disease. J Endometr. 2011 Sep 30;3(3):135-142.

• Shipping Conditions:

  Room Temperature

• Clinical Information:

  Phase 1

• CAS Number:

  478336-92-4