CP-615003

CAT: 0804-HY-165444Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-165444Size:1 Each
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Description
CP-615003 is a potent and subtype-selective partial agonist of GABAA receptor (GABAA receptor) (Ki = 1.1 μM) . CP-615003 is mainly converted into the active metabolite CP-900725 through oxidative deamination in monkeys and humans, and the latter also has GABAA receptor affinity. CP-615003 is a substrate of P-glycoprotein (P-gp/MDR1), resulting in severe limitation of its penetration into the central nervous system (CNS) . CP-615003 can be used for the study of CNS-related indications[1].
CAS Number
[329016-45-7]
Product Name Alternative
NGD-913
UNSPSC
12352005
Target
GABA Receptor
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Field of Research
Neurological Disease
Smiles
O=C(C1=CNC2=C1C(CCC2)=O)NC3=CC=C(C(F)=C3)OCCNCCC
Molecular Formula
C20H24FN3O3
Molecular Weight
373.42
References & Citations
[1]Venkatakrishnan K, et al. Central nervous system pharmacokinetics of the Mdr1 P-glycoprotein substrate CP-615,003: intersite differences and implications for human receptor occupancy projections from cerebrospinal fluid exposures. Drug metabolism and disposition. 2007 Aug 1;35 (8) :1341-9.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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