TU-100

• Description :

  TU-100 is a Japanese herbal medicine. TU-100 exhibits anti-cancer effects by regulating cancer-associated fibroblasts (CAFs) in the TME. TU-100 can antagonize the M2 polarization phenotype of macrophages in the tumor microenvironment by suppressing the TLR4/NF-κB/STAT3 axis. TU-100 can inhibit the high expression of MMP-2, COX-2, and VEGF in TAMs[1].

• CAS Number :

  [1310907-71-1]

• UNSPSC :

  12352005

• Target :

  COX; MMP; NF-κB; STAT; Toll-like Receptor (TLR) ; VEGFR

• Related Pathways :

  Immunology/Inflammation; JAK/STAT Signaling; Metabolic Enzyme/Protease; NF-κB; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

• Field of Research :

  Cancer

• Smiles :

  O=C1C2=C(C(C3=C1C4C(C5=C(C3N4C)C=CC=C5)=O)=O)C=CC=C2

• Molecular Formula :

  C20H13NO3

• Molecular Weight :

  315.32

• References & Citations :

  [1]Chen S, et al. TU-100 Antagonizes the M2 Polarization Phenotype of Macrophages in the Tumor Microenvironment by Suppressing the TLR4/NF-B/STAT3 Axis. Anticancer Res. 2023 May;43 (5) :1985-1992.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  COX-2; MMP-2; STAT3; TLR4