Products for Research Use Only
RegisterLogin

DGY-09-192

CAT: 0804-HY-165298-01Size: 1 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-165298-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
DGY-09-192 is a PROTAC FGFR1/2 degrader (FGFR1: DC50 = 4.35 nM; FGFR2: DC50 = 70 nM). DGY-09-192 preferentially degrades wild-type FGFR1/2 and multiple FGFR2 fusion proteins (including FGFR2-PHGDH and FGFR2-OPTN). DGY-09-192 suppresses downstream FGFR signaling (reducing phosphorylation of FRS2 Y196 and ERK1/2 T202/Y204) in vitro and vivo. DGY-09-192 can be used for the study of FGFR-driven cancers. (Pink: FGFR1/2 ligand , Blue: VHL Ligand (HY-112078), Black: Linker (HY-W020017) ).
CAS Number
2504949-52-2
UNSPSC
12352005
Target
ERK; FGFR; PROTACs
Related Pathways
MAPK/ERK Pathway; PROTAC; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Field of Research
Cancer
Purity
99.50
Solubility
DMSO : ≥ 100 mg/mL
Smiles
ClC(C(OC)=CC(OC)=C1Cl)=C1NC(N(C)C2=CC(NC(C=C3)=CC=C3N(CC4)CCN4CC(N[C@@H](C(C)(C)C)C(N5[C@@H](C[C@H](C5)O)C(N[C@H](C6=CC=C(C7=C(N=CS7)C)C=C6)C)=O)=O)=O)=NC=N2)=O
Molecular Formula
C49H59Cl2N11O7S
Molecular Weight
1017.03
References & Citations
[1]Du G, et al. Discovery of a Potent Degrader for Fibroblast Growth Factor Receptor 1/2. Angew Chem Int Ed Engl. 2021 Jul 12;60 (29) :15905-15911.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
FGFR1; FGFR2; von Hippel-Lindau (VHL)

Related Products

CatalogName
HY-136605-01DGY-06-116
HY-110264MI-192
HY-W998256DGY-02-126-O-C-COOH
HY-149263HAA-09
HY-P1439-01RS 09
HY-103666-01CY-09
HY-16704-01ESI-09
HY-12840-01OBA-09
HY-157931Anticancer agent 192
HY-136861Antibacterial agent 192

Alternative Products

CatalogName
GTR19275100-01DGY-09-192
BA9020-100DGY-06-116
T69643-01DGY-08-097
A22077-50DGY-06-116 50mg

Popular Products