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SBI-810 (hydrochloride)

CAT: 0804-HY-164795A-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-164795A-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SBI-810 hydrochloride is a functionally selected β-arrestin-biased neurotensin receptor 1 (NTSR1) allosteric modulator. SBI-810 hydrochloride modulates NTSR1 G protein signaling in a G protein-specific manner in the presence of the endogenous ligand, neurotensin (NT) . SBI-810 hydrochloride fully antagonizes NT-induced activation of Gq, partially antagonizes NT-induced activation of Gi1 and is permissive of NTSR1 activation of GoA and G12[1][2].
CAS Number
2772746-58-2
UNSPSC
12352005
Target
Neurotensin Receptor
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Neurological Disease
Purity
99.55
Solubility
DMSO : 12.5 mg/mL (ultrasonic)
Smiles
OCCN(C)C1=CC2=C(N=C(C3(CC3)C)N=C2N4CCC(CC4)C5=C(OC)C=CC=C5)C=C1.Cl
Molecular Formula
C27H35ClN4O2
Molecular Weight
483.05
References & Citations
[1]Lawrence Barak, et al. Compositions for and methods of treating and/or preventing pain. WO2022241186A1. 2022 November 17.|[2]Center M N A, et al. Summer Undergraduate Research Expo[J]. 2014.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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